Darin Tsui

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Hi there! My name is Darin. I’m a Ph.D. student at the Georgia Institute of Technology studying Electrical and Computer Engineering and Bioengineering. I previously received my BS degree at the University of California San Diego in Bioengineering.

I currently work with Dr. Amirali Aghazadeh in the AI ML & Information Group, where I develop scalable, interpretable tools for generative models in the biosciences. I am currently supported by the NSF Graduate Research Fellowship. My research focuses on:

  • Explaining black-box models by bridging the gap between interpretability and signal processing.

  • Extracting higher-order interactions from models for scientific discovery.

  • Developing principled generative models that leverage domain priors.

My background is highlighly interdisciplinary. I previously validated deep learning models at Surgalign (acquired by Xtant Medical), developed an optical surgical platform in the Talke Biomedical Device Lab, and designed a bioelectronic COVID-19 test in the Integrated Systems Neuroengineering Laboratory.

Outside of research, I co-chair Bioengineering Day at Georgia Tech, which aims to highlight interdisciplinary research . Previously, I served as President of the IEEE student branch and helped found the IEEE EMBS chapter at UC San Diego.

News

Jul 16, 2025 Our work on assessing and explaining mutations in myocilin was accepted to the Machine Learning in Computational Biology (MLCB) meeting.
Jun 27, 2025 My work on developing sparse Fourier transforms for generalized q-ary functions was accepted to the IEEE Information Theory Workshop (ITW).
May 11, 2024 I presented my work on uncovering higher-order interactions in protein language models at the ICLR Generative and Experimental Perspectives for Biomolecular Design (GEM) workshop.
Apr 04, 2024 Excited to announce that I was awarded the National Science Foundation (NSF) Graduate Research Fellowship (GRFP) to support my PhD!
Aug 31, 2023 I had the opportunity to give a talk at the ASME Information Storage and Processing Systems (ISPS) on the promise of stereoscopic vision in computer-assisted surgery.

Selected Publications

  1. BipartiteGraph.png
    Efficient algorithm for sparse Fourier transform of generalized q-ary functions
    Darin Tsui, Kunal Talreja , and Amirali Aghazadeh
    In 2025 IEEE Information Theory Workshop (ITW) (Accepted) , 2025
  2. SHAPzero_logo.png
    SHAP zero explains biological sequence models with near-zero marginal cost for future queries
    Darin Tsui, Aryan Musharaf , Yigit Efe Erginbas , and 2 more authors
    arXiv preprint arXiv:2410.19236, 2025
  3. ICLR2024.png
    On recovering higher-order interactions from protein language models
    Darin Tsui, and Amirali Aghazadeh
    In ICLR 2024 Workshop on Generative and Experimental Perspectives for Biomolecular Design (GEM) , 2024