Publications

2026

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    Protein fitness landscapes are simpler under evolutionary distributions
    Darin Tsui, Kunal Talreja , and Amirali Aghazadeh
    bioRxiv, 2026
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  2. ProGenMech.png
    Circuit tracing in autoregressive protein language models
    Darin Tsui, William Deinzer , Daniel Saeedi , and 1 more author
    In Mechanistic Interpretability Workshop at ICML , 2026
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    Spectral sparsity: A unifying framework for scalable model interpretability using codes
    Justin S. Kang , Darin Tsui, Yigit Efe Erginbas , and 3 more authors
    IEEE BITS the Information Theory Magazine, 2026
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    Protein circuit tracing via cross-layer transcoders
    Darin Tsui, Kunal Talreja , Daniel Saeedi , and 1 more author
    In International Conference on Machine Learning (ICML) , 2026
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    cryoSENSE: compressive sensing enables high-throughput microscopy with sparse and generative priors on the protein cryo-EM image manifold
    Zain Shabeeb , Daniel Saeedi , Darin Tsui, and 2 more authors
    In Conference on Computer Vision and Pattern Recognition (CVPR) , 2026
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2025

  1. SHAPzero.png
    SHAP zero explains biological sequence models with near-zero marginal cost for future queries
    Darin Tsui, Aryan Musharaf , Yigit Efe Erginbas , and 2 more authors
    In Conference on Neural Information Processing Systems (NeurIPS) , 2025
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    SpecMER: Fast protein generation with K-mer guided speculative decoding
    Thomas Walton , Darin Tsui, Aryan Musharaf , and 1 more author
    In NeurIPS (Spotlight) , 2025
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  3. LowNSAE.png
    Sparse autoencoders for low-N protein function prediction and design
    Darin Tsui, Kunal Talreja , and Amirali Aghazadeh
    In NeurIPS AI4Science Workshop , 2025
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    GOLF: A generative AI framework for pathogenicity prediction of myocilin OLF variants
    Thomas Walton , Darin Tsui, Lauren Fogel , and 4 more authors
    In Machine Learning in Computational Biology , 2025
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  5. ITW.jpg
    Efficient algorithm for sparse Fourier transform of generalized q-ary functions
    Darin Tsui, Kunal Talreja , and Amirali Aghazadeh
    In IEEE Information Theory Workshop (ITW) , 2025
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2024

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    On recovering higher-order interactions from protein language models
    Darin Tsui, and Amirali Aghazadeh
    In ICLR Workshop on Generative and Experimental Perspectives for Biomolecular Design (GEM) , 2024
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  2. Microsys.png
    A low-cost, open-source-based optical surgical navigation system using stereoscopic vision
    Darin Tsui, Kirsten Ramos , Capalina Melentyev , and 5 more authors
    Microsystem Technologies, 2024
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2023

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    An optical tracking approach to computer-assisted surgical navigation via stereoscopic vision
    Darin Tsui, Capalina Melentyev , Ananya Rajan , and 2 more authors
    In ASME 2023 32nd Conference on Information Storage and Processing Systems (ISPS) , 2023
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    A machine learning approach to COVID-19 detection via graphene field-effect-transistor (GFET)
    Darin Tsui, Francisco Downey , Shreenithi Navaneethan , and 6 more authors
    In 2023 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) , 2023
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    Optical surgical navigation: a promising low-cost alternative
    Darin Tsui, Mitsuhiro Jo , Bryan Nguyen , and 2 more authors
    In 2023 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) , 2023
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